Scientist Downstream Process Development | VectorY


Scientist Downstream Process Development | VectorY

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the potential of antibodies and gene therapy to develop long-lasting therapeutic solutions for disease areas of high unmet medical need.

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated gene therapy company focused on the development of innovative therapeutics.

With R&D facilities in Amsterdam, VectorY develops proprietary & partnered programs based on its novel AAV-based vectorized antibody gene therapy platform. Next generation vector technologies are applied to develop product candidates, which will enable a proprietary and highly scalable manufacturing process.

Your position within the organization

The Process Development (PD) department is an essential part of VectorY, which is taking the lead for the in-house development, scale-up and manufacture of novel gene therapies. The downstream processing (DSP) team is responsible for recovering and purifying the biopharmaceutical from the bioreactor harvest through a sequence of unit operations, including cell lysis, filtration, chromatography, and UF/DF. The DSP team will also support tech transfer to Contract Manufacturing Organizations (CMOs) for the manufacture of AAV-based gene therapies for clinical trials.

The main responsibilities of the role

  • Make study designs to develop and optimize the downstream manufacturing process

  • Apply Design of Experiments (DoE) to aid efficient process development and use of Quality by Design principles

  • Process development at a small scale of each unit operation (processing 2 – 16 L harvest)

  • Scale up and further optimize the manufacturing process to pilot scale (processing 50 L harvest) •

  • Manage the day-to-day downstream process development execution by a team of technicians

  • Manage the technical execution of projects to meet the set timelines and deliverables • Develop training plans and mentor (junior) technicians and students

  • Write SOPs and document the work in study plans and reports. Draft the manufacturing documentation

  • Secure data management, processing of the results and presentation to key stakeholders

  • Work collaboratively with scientists in Upstream Process Development, Vector Development and Analytical Development

Skills and Qualifications:

  • Ph.D., with a minimum of 2 years of relevant working experience

  • Hands-on experience with small-scale chromatography and ultrafiltration equipment required, preferably with AKTA systems

  • Industrial experience with the development of the manufacturing process for biopharmaceuticals, such as vaccines or gene therapies is considered a plus

  • Experience in upstream processing is considered a plus

Your Natural Strengths and Drivers

You are thorough, have strong scientific and organizational skills, and have the ability to distinguish main priorities from lower-priority matters. You deliver well-thought-through study designs and work consistently and at a steady pace.

Working at VectorY

We offer an attractive salary package, 30 holiday days and every opportunity to develop yourself. A personal and authentic experience within a young, ambitious biotech company with a strong and established infrastructure on the path to bring innovative therapies to patients worldwide.


VectorY at a glance

Our mission

We are an Amsterdam-based biotech company founded in 2020 with a mission to develop vectorized antibody treatments for people with neurodegenerative diseases, enabling longer, better lives.

Antibody treatments have wide applicability in neurodegenerative diseases that are known to be complex and difficult to treat. Our cutting-edge vectorized antibody technology combines highly selective therapeutic antibodies with one-time AAV-based delivery to the CNS. We are advancing a development pipeline of potentially disease-modifying treatments for ALS, Huntington’s, and Parkinson’s disease.

Our vectorized antibody platform

Our expert team has developed a unique platform with state-of-the-art intracellular antibodies, engineered capsids and scalable AAV manufacturing processes. With this broad in-house expertise our team is uniquely positioned to rapidly discover and develop new therapies.

Read about our technology

Our programs

We have a strong pipeline of potentially disease-modifying vectorized antibody treatments for neurodegenerative diseases including ALS, Huntington’s, and Parkinson’s disease.

View pipeline

Strong Leadership

Our leaders on the Management Team, Board of Directors and Scientific Advisory Board have a proven track record in the development of new drugs as well as extensive business and scientific expertise.

View VectorY’s Leadership

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