Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the potential of antibodies and gene therapy to develop long-lasting therapeutic solutions for disease areas of high unmet medical need.

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated gene therapy company focused on the development of innovative therapeutics.

With R&D facilities in Amsterdam, VectorY develops proprietary & partnered programs based on its novel AAV-based vectorized antibody gene therapy platform. Next generation vector technologies are applied to develop product candidates, which will enable a proprietary and highly scalable manufacturing process.

Your position within the organization

The Process Development (PD) department is an essential part of VectorY, which is taking the lead for the in-house development, scale-up and manufacture of novel gene therapies. The downstream processing (DSP) team is responsible for recovering and purifying the biopharmaceutical from the bioreactor harvest through a sequence of unit operations, including cell lysis, filtration, chromatography, and UF/DF. The DSP team will also support tech transfer to Contract Manufacturing Organizations (CMOs) for the manufacture of AAV-based gene therapies for clinical trials.

The main responsibilities of the role

• Make study designs to develop and optimize the downstream manufacturing process

• Apply Design of Experiments (DoE) to aid efficient process development and use of Quality by Design principles

• Process development at a small scale of each unit operation (processing 2 – 16 L harvest)

• Scale up and further optimize the manufacturing process to pilot scale (processing 50 L harvest) •

• Manage the day-to-day downstream process development execution by a team of technicians

• Manage the technical execution of projects to meet the set timelines and deliverables • Develop training plans and mentor (junior) technicians and students

• Write SOPs and document the work in study plans and reports. Draft the manufacturing documentation

• Secure data management, processing of the results and presentation to key stakeholders

• Work collaboratively with scientists in Upstream Process Development, Vector Development and Analytical Development

Skills and Qualifications:

• Ph.D., with a minimum of 2 years of relevant working experience

• Hands-on experience with small-scale chromatography and ultrafiltration equipment required, preferably with AKTA systems

• Industrial experience with the development of the manufacturing process for biopharmaceuticals, such as vaccines or gene therapies is considered a plus

• Experience in upstream processing is considered a plus

Your Natural Strengths and Drivers

You are thorough, have strong scientific and organizational skills, and have the ability to distinguish main priorities from lower-priority matters. You deliver well-thought-through study designs and work consistently and at a steady pace.

Working at VectorY

We offer an attractive salary package, 30 holiday days and every opportunity to develop yourself. A personal and authentic experience within a young, ambitious biotech company with a strong and established infrastructure on the path to bring innovative therapies to patients worldwide.